The origin recognition complex (ORC) binds sites from which DNA replication is initiated. By mapping binding sites in human cells, we show that ORC binds selectively to open (DNase I-hypersensitive) ...

After a year of input and development to the class rules and the Velocity Prediction Program (VPP), and several weeks after their approval at the ORC Annual General Meeting in November, the Offshore ...

In eukaryotes, the Cdt1-bound replicative helicase core MCM2-7 is loaded onto DNA by the ORC–Cdc6 ATPase to form a prereplicative complex (pre-RC) with an MCM2-7 double hexamer encircling DNA. Using ...

The Offshore Racing Congress (ORC) is pleased to announce the new rules and regulations for this year's 2024 season of racing are now available online here. These rules cover a range of topics related ...