Bidirectional DNA replication, in which two replication forks travel in opposite directions from each origin of replication, is required for complete genome duplication. To prepare for this event, two ...

The Orsimer, also called Pariah Folk or Orc, are the native people of the Wrothgarian and Dragontail Mountains. These are said to be barbarian by most of the other races on Nirn and can be quite ...

The origin recognition complex (ORC) binds sites from which DNA replication is initiated. By mapping binding sites in human cells, we show that ORC binds selectively to open (DNase I-hypersensitive) ...

To initiate DNA replication, the origin recognition complex (ORC) and Cdc6 load an Mcm2–7 double hexamer onto DNA. Without ATP hydrolysis, ORC–Cdc6 recruits one Cdt1-bound Mcm2–7 hexamer, thus forming ...