Prostate cancer remains dependent of androgen receptor (AR) signalling, even after emergence of castration resistance. EZN-4176 is a third-generation antisense oligonucleotide that binds to the hinge ...

EZN-2968 was generally well tolerated without significant toxicity (Table 2). A 77-year-old male patient with multiple liver metastases who had grade 1 AST elevation at baseline demonstrated worsening ...

Background: The HER family consists of four tyrosine kinase receptors designated as EGFR, HER2, HER3 and HER4. Numerous new studies now indicated that HER3 plays a critical role in cancer development ...

Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that plays a critical role in angiogenesis, survival, metastasis, drug resistance, and glucose metabolism. Elevated expression of the alpha ...

This study looked at a drug called EZN 4176 for prostate cancer that has spread to another part of the body and is no longer responding to hormone therapy. Doctors often use hormone therapy to treat ...